For tourists from the US, Canada, UK, Australia, and most EU countries:
The dry season from mid-October to April is the best time for outings in Cambodia due to its mild air, clear blue skies, and minimal rainfall. From May to September, even though it's the rainy season, the rain typically only lasts for an hour or two a day. The rest of the day is usually sunny, and visits are still feasible.
Yes, it is entirely possible to reach Cambodia by air. You can take a flight from Ho Chi Minh (or Hanoi) to Siem Reap and spend the rest of your journey exploring the magnificent Angkorian temples.